Indomethacin

Name Indomethacin
Supplier Tocris Bioscience
Catalog 1813
Prices $95.00
Sizes 100 mg
Function Type Inhibitor
Cas Number 53-86-1
Chemical Name 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole
Formula C19H16ClNO4
Molecular Weight 357.79
Purity >99 %
Description Cyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC 50 values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent.
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Product References

Indomethacin, a new anti-inflammatory drug: its potential use as a laboratory - Indomethacin, a new anti-inflammatory drug: its potential use as a laboratory

Walters MN, Willoughby DA. J Pathol Bacteriol. 1965 Oct;90(2):641-8.

Chemical and biological studies on indomethacin, sulindac and their analogs. - Chemical and biological studies on indomethacin, sulindac and their analogs.

Shen TY, Winter CA. Adv Drug Res. 1977;12:90-245.

Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore - Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore

Palomer A, Cabre F, Pascual J, Campos J, Trujillo MA, Entrena A, Gallo MA, Garcia L, Mauleon D, Espinosa A. J Med Chem. 2002 Mar 28;45(7):1402-11.