INDY

• Supplier: Tocris Bioscience
• Catalog: 1708
• Prices: $165.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 1169755-45-6
• Chemical Name: (1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone
• Formula: C12H13NO2S
• Molecular Weight: 235.3
• Purity: >98 %
• Description: DYRK1A/B inhibitor (IC 50 values are 0.23 and 0.24 μ M, for DYRK1B and DYRKA respectively). Binds at the ATP-binding cleft of the enzyme. Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of subventricular zone neural stem cells. Also available as a prodrug, proINDY (Cat. No. 4998).

Product References

Development of a novel selective inhibitor of the Down syndrome-related kinase - Development of a novel selective inhibitor of the Down syndrome-related kinase

Ogawa Y, Nonaka Y, Goto T, Ohnishi E, Hiramatsu T, Kii I, Yoshida M, Ikura T, Onogi H, Shibuya H, Hosoya T, Ito N, Hagiwara M. Nat Commun. 2010 Oct 5;1:86.

Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma - Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma

Pozo N, Zahonero C, Fernandez P, Linares JM, Ayuso A, Hagiwara M, Perez A, Ricoy JR, Hernandez-Lain A, Sepulveda JM, Sanchez-Gomez P. J Clin Invest. 2013 Jun;123(6):2475-87.