D- myo -Inositol-1,3,4,5- tetrakis phosphate, octapotassium salt

Name D- myo -Inositol-1,3,4,5- tetrakis phosphate, octapotassium salt
Supplier Tocris Bioscience
Catalog 3551
Prices $199.00
Sizes 100 µg
Cas Number 145843-69-2
Formula C6H8O18P4.K8
Molecular Weight 804.73
Purity >98 %
Description Phosphorylation product of inositol 1,4,5-trisphosphate (Ins (1,4,5)P 3 ). Potent inhibitor of Ins (1,4,5)P 3 5-phosphatase (IC 50 ~150 nM); facilitates Ca 2+ influx by sensitizing Ins (1,4,5)P 3 -mediated activation of I CRAC . At higher concentrations, acts as an inhibitor of Ins (1,4,5)P 3 receptors.
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Product References

Agonist-induced calcium signaling is impaired in fibroblasts overproducing - Agonist-induced calcium signaling is impaired in fibroblasts overproducing

Balla T, Sim SS, Iida T, Choi KY, Catt KJ, Rhee SG. J Biol Chem. 1991 Dec 25;266(36):24719-26.

Bridging the GAP in inositol 1,3,4,5-tetrakisphosphate signalling. - Bridging the GAP in inositol 1,3,4,5-tetrakisphosphate signalling.

Cullen PJ. Biochim Biophys Acta. 1998 Dec 8;1436(1-2):35-47.

InsP4 facilitates store-operated calcium influx by inhibition of InsP3 - InsP4 facilitates store-operated calcium influx by inhibition of InsP3

Hermosura MC, Takeuchi H, Fleig A, Riley AM, Potter BV, Hirata M, Penner R. Nature. 2000 Dec 7;408(6813):735-40.