5-Iodo-A-85380 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3435
• Prices: $279.00
• Sizes: 10 mg
• Function Type: Agonist
• Cas Number: 1217837-17-6
• Chemical Name: 3-[(2S)-2-Azetidinylmethoxy]-5-iodopyridinedihydrochloride
• Formula: C9H11IN2O.2HCl
• Molecular Weight: 363.03
• Purity: >99 %
• Description: A highly potent and subtype-selective agonist for the α 4 β 2 and α 6 β 2 nicotinic acetylcholine receptors. Activates α -CTx-MII-sensitive and -insensitive components of [ 3 H]dopamine release from rat striatal synaptosomes, corresponding to α 6 β 2 and α 4 β 2 (EC 50 values are 12.7 and ~35 nM respectively). ~5000- , 25000- and 140000-fold selective over α 3 β 4, α 7 and muscle nAChR receptors respectively. Precursor (Cat. No. 1527) also available.

Product References

2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for - 2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for

Koren AO, Horti AG, Mukhin AG, Gundisch D, Kimes AS, Dannals RF, London ED. J Med Chem. 1998 Sep 10;41(19):3690-8.

5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic - 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic

Mukhin AG, Gundisch D, Horti AG, Koren AO, Tamagnan G, Kimes AS, Chambers J, Vaupel DB, King SL, Picciotto MR, Innis RB, London ED. Mol Pharmacol. 2000 Mar;57(3):642-9.

Functional responses and subunit composition of presynaptic nicotinic receptor - Functional responses and subunit composition of presynaptic nicotinic receptor

Mogg AJ, Jones FA, Pullar IA, Sharples CG, Wonnacott S. Neuropharmacology. 2004 Nov;47(6):848-59.