( S )-(-)-5-Iodowillardiine

Name ( S )-(-)-5-Iodowillardiine
Supplier Tocris Bioscience
Catalog 1745
Prices $189.00, $765.00
Sizes 10 mg, 50 mg
Cas Number 140187-25-3
Formula C7H8IN3O4
Molecular Weight 325.06
Purity >98 %
Description Demonstrates high affinity for the kainate receptor subtype hGluR5 (K i = 0.24 nM) and 600-4000-fold selectivity over both the AMPA receptor subtypes and the homomeric kainate receptor hGluR6.
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Product References

Activation and desensitization of AMPA/kainate receptors by novel derivatives of - Activation and desensitization of AMPA/kainate receptors by novel derivatives of

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Willardiines differentiate agonist binding sites for kainate- versus - Willardiines differentiate agonist binding sites for kainate- versus

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Synthesis of willardiine and 6-azawillardiine analogs: pharmacological - Synthesis of willardiine and 6-azawillardiine analogs: pharmacological

Jane DE, Hoo K, Kamboj R, Deverill M, Bleakman D, Mandelzys A. J Med Chem. 1997 Oct 24;40(22):3645-50.

Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine. - Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine.

Swanson GT, Green T, Heinemann SF. Mol Pharmacol. 1998 May;53(5):942-9.