IP7e

• Supplier: Tocris Bioscience
• Catalog: 4451
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 500164-74-9
• Chemical Name: 6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one
• Formula: C23H22N2O4
• Molecular Weight: 390.43
• Purity: >98 %
• Description: Potent Nurr1 activator (EC 50 = 3.9 nM). Delays onset and reduces severity of symptoms in mice with experimental autoimmune encephalomyelitis (EAE). Also suppresses NF- κ B signaling. Brain penetrant and orally bioavailable.

Product References

p21-activated kinases in cancer. - p21-activated kinases in cancer.

Kumar R, Gururaj AE, Barnes CJ. Nat Rev Cancer. 2006 Jun;6(6):459-71.

An isoform-selective, small-molecule inhibitor targets the autoregulatory - An isoform-selective, small-molecule inhibitor targets the autoregulatory

Deacon SW, Beeser A, Fukui JA, Rennefahrt UE, Myers C, Chernoff J, Peterson JR. Chem Biol. 2008 Apr;15(4):322-31.

Membrane transport of WAVE2 and lamellipodia formation require Pak1 that mediates - Membrane transport of WAVE2 and lamellipodia formation require Pak1 that mediates

Takahashi K, Suzuki K. Cell Signal. 2009 May;21(5):695-703.

An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory - An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory

Viaud J, Peterson JR. Mol Cancer Ther. 2009 Sep;8(9):2559-65.