IRL-2500

• Supplier: Tocris Bioscience
• Catalog: 3000
• Prices: $249.00
• Sizes: 10 mg
• Function Type: Antagonist
• Cas Number: 169545-27-1
• Chemical Name: N-3-[1,1'-Biphenyl]-4-yl-N-(3,5-dimethylbenzoyl)-N-methyl-D-alanyl-L-tryptophan
• Formula: C36H35N3O4
• Molecular Weight: 573.69
• Purity: >99 %
• Description: Potent endothelin receptor antagonist; shows some selectivity for ET B receptors (IC 50 values are 1.3 and 94 nM for ET B and ET A receptors respectively). Inhibits ET B receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo .

Product References

Characterization of a potent and selective endothelin-B receptor antagonist, IRL - Characterization of a potent and selective endothelin-B receptor antagonist, IRL

Balwierczak JL, Bruseo CW, DelGrande D, Jeng AY, Savage P, Shetty SS. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S393-6.

Effects of the ETB-selective antagonist IRL 2500 in conscious spontaneously - Effects of the ETB-selective antagonist IRL 2500 in conscious spontaneously

Webb RL, Navarrete AE, Ksander GM. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S389-92.

Use of A-192621 and IRL-2500 to unmask the mesenteric and renal vasodilator role - Use of A-192621 and IRL-2500 to unmask the mesenteric and renal vasodilator role

Leung SW, Lim SL, Pang CC, Man RY. J Cardiovasc Pharmacol. 2002 Apr;39(4):533-43.