Irsogladine maleate

• Supplier: Tocris Bioscience
• Catalog: 1196
• Prices: $129.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 84504-69-8
• Chemical Name: 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diaminemaleate
• Formula: C9H7Cl2N5.C4H4O4
• Molecular Weight: 372.18
• Purity: >99 %
• Description: Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.

Product References

Phosphodiesterase type IV inhibitors prevent ischemia-reperfusion-induced gastric - Phosphodiesterase type IV inhibitors prevent ischemia-reperfusion-induced gastric

Kyoi T, Kitazawa S, Tajima K, Zhang X, Ukai Y. J Pharmacol Sci. 2004 Jul;95(3):321-8.

Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting - Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting

Kyoi T, Noda K, Oka M, Ukai Y. Life Sci. 2004 Nov 19;76(1):71-83.

Inhibition of breast cancer regrowth and pulmonary metastasis in nude mice by - Inhibition of breast cancer regrowth and pulmonary metastasis in nude mice by

Nozaki S, Maeda M, Tsuda H, Sledge GW Jr. Breast Cancer Res Treat. 2004 Feb;83(3):195-9.