ISO 1

• Supplier: Tocris Bioscience
• Catalog: 4695
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 478336-92-4
• Chemical Name: 4,5-Dihydro-3-(4-hydroxyphenyl)-5-isoxazoleaceticacidmethylester
• Formula: C12H13NO4
• Molecular Weight: 235.24
• Purity: >98 %
• Description: Macrophage migration inhibitory factor (MIF) inhibitor (IC 50 = 7 μ M); inhibits MIF tautomerase activity in vitro and in vivo . Protective against mouse models of streptozotocin-induced diabetes mellitus; blocks anti-inflammatory response following LPS exposure and increases survival. Inhibits airway remodeling in a mouse model of chronic asthma. Cell permeable; orally bioavailable.

Product References

The tautomerase active site of macrophage migration inhibitory factor is a - The tautomerase active site of macrophage migration inhibitory factor is a

Lubetsky JB, Dios A, Han J, Aljabari B, Ruzsicska B, Mitchell R, Lolis E, Al-Abed Y. J Biol Chem. 2002 Jul 12;277(28):24976-82. Epub 2002 May 7.

ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory - ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory

Al-Abed Y, Dabideen D, Aljabari B, Valster A, Messmer D, Ochani M, Tanovic M, Ochani K, Bacher M, Nicoletti F, Metz C, Pavlov VA, Miller EJ, Tracey KJ. J Biol Chem. 2005 Nov 4;280(44):36541-4. Epub 2005 Aug 22.

Critical role of macrophage migration inhibitory factor activity in experimental - Critical role of macrophage migration inhibitory factor activity in experimental

Cvetkovic I, Al-Abed Y, Miljkovic D, Maksimovic-Ivanic D, Roth J, Bacher M, Lan HY, Nicoletti F, Stosic-Grujicic S. Endocrinology. 2005 Jul;146(7):2942-51. Epub 2005 Mar 24.

ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway - ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway

Chen PF, Luo YL, Wang W, Wang JX, Lai WY, Hu SM, Cheng KF, Al-Abed Y. Mol Med. 2010 Sep-Oct;16(9-10):400-8.