Isotretinoin

• Supplier: Tocris Bioscience
• Catalog: 1747
• Prices: $59.00
• Sizes: 50 mg
• Function Type: Agonist
• Cas Number: 4759-48-2
• Chemical Name: 13-cis-Retinoicacid
• Formula: C20H28O2
• Molecular Weight: 300.44
• Purity: >99 %
• Description: Endogenous agonist for retinoic acid receptors. Promotes neurite outgrowth, cell differentiation and inhibits proliferation in a neuroblastoma cell line. Also increases protein expression levels of MYCN and retinoic acid receptor- β . Anti-inflammatory.

Product References

Cellular metabolism and actions of 13-cis-retinoic acid. - Cellular metabolism and actions of 13-cis-retinoic acid.

Blaner WS. J Am Acad Dermatol. 2001 Nov;45(5):S129-35.

Chemical genetics reveals a complex functional ground state of neural stem cells. - Chemical genetics reveals a complex functional ground state of neural stem cells.

Diamandis P, Wildenhain J, Clarke ID, Sacher AG, Graham J, Bellows DS, Ling EK, Ward RJ, Jamieson LG, Tyers M, Dirks PB. Nat Chem Biol. 2007 May;3(5):268-73. Epub 2007 Apr 8.

Metabolic characteristics of 13-cis-retinoic acid (isotretinoin) and anti-tumour - Metabolic characteristics of 13-cis-retinoic acid (isotretinoin) and anti-tumour

Sonawane P, Cho HE, Tagde A, Verlekar D, Yu AL, Reynolds CP, Kang MH. Br J Pharmacol. 2014 Dec;171(23):5330-44.