ISOX DUAL

• Supplier: Tocris Bioscience
• Catalog: 5513
• Prices: $235.00, $965.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Chemical Name: [3-[4-[2-[5-(Dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-1H-1,3-benzodiazol-2-yl]ethyl]phenoxy]propyl]dimethylamine
• Formula: C31H41N5O3
• Molecular Weight: 531.69
• Purity: >98 %
• Description: Dual CBP/p300 and BRD4 bromodomain inhibitor (IC 50 values are 0.65 and 1.5 μ M for CBP and BRD4 respectively). Downregulates IL-6 , IL-1 β and IFN- β in macrophages.

Product References

Increased therapeutic potential of an experimental anti-mitotic inhibitor - Increased therapeutic potential of an experimental anti-mitotic inhibitor

Davis DA, Sarkar SH, Hussain M, Li Y, Sarkar FH. BMC Cancer. 2006 Jan 24;6:22.

Mechanism of inhibition of human KSP by ispinesib. - Mechanism of inhibition of human KSP by ispinesib.

Lad L, Luo L, Carson JD, Wood KW, Hartman JJ, Copeland RA, Sakowicz R. Biochemistry. 2008 Mar 18;47(11):3576-85.

Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models - Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models

Purcell JW, Davis J, Reddy M, Martin S, Samayoa K, Vo H, Thomsen K, Bean P, Kuo WL, Ziyad S, Billig J, Feiler HS, Gray JW, Wood KW, Cases S. Clin Cancer Res. 2010 Jan 15;16(2):566-76.