| Name | Isradipine |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5408 |
| Prices | $129.00, $535.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Blocker |
| Cas Number | 75695-93-1 |
| Chemical Name | 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylicacidmethyl1-methylethylester |
| Formula | C19H21N3O5 |
| Molecular Weight | 371.39 |
| Purity | >99 % |
| Description | Potent and selective L-type voltage-gated Ca 2+ channel blocker. EC 50 and pA 2 values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca 2+ -induced contractions of rabbit aorta respectively; EC 25 = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo , exerting primary effects on vascular tissue with secondary negative chronotropic action. |
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Hof RP, Scholtysik G, Loutzenhiser R, Vuorela HJ, Neumann P. J Cardiovasc Pharmacol. 1984 May-Jun;6(3):399-406.
Wada Y, Satoh K, Taira N. J Cardiovasc Pharmacol. 1985 Jan-Feb;7(1):190-6.