trans-ISRIB

• Supplier: Tocris Bioscience
• Catalog: 2004
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1597403-47-8
• Chemical Name: N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]
• Formula: C22H24Cl2N2O4
• Molecular Weight: 451.34
• Purity: >99 %
• Description: Integrated stress response (ISR) inhibitor; reverses the effects of eIF2 α phosphorylation (IC 50 = 5 nM) and restores cell translation capacity. Acts downstream of PERK, targeting interactions between eIF2 α kinases and elF2B. Blocks ATF4 production without altering the IRE1 or ATF6 responses in vitro . Displays memory enhancement in hippocampus-dependent spatial and fear-associated learning in rodents. Brain penetrant.

Product References

Pharmacological brake-release of mRNA translation enhances cognitive memory. - Pharmacological brake-release of mRNA translation enhances cognitive memory.

Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, Renslo AR, Sonenberg N, Walter P. Elife. 2013 May 28;2:e00498.

Cell biology. Blocking stress response for better memory? - Cell biology. Blocking stress response for better memory?

Hinnebusch AG. Science. 2015 May 29;348(6238):967-8.

Stress responses. Mutations in a translation initiation factor identify the - Stress responses. Mutations in a translation initiation factor identify the

Sekine Y, Zyryanova A, Crespillo-Casado A, Fischer PM, Harding HP, Ron D. Science. 2015 May 29;348(6238):1027-30.