Istradefylline

Name Istradefylline
Supplier Tocris Bioscience
Catalog 5284
Prices $159.00, $665.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 155270-99-8
Chemical Name 8-[(1E)-2-(2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione
Formula C20H24N4O4
Molecular Weight 384.43
Purity >99 %
Description Potent and selective adenosine A 2A receptor antagonist (K i values are 2.2 and 150 nM for A 2A and A 1 receptors respectively). Anticataleptic and antiparkinson agent; reverses drug-induced motor dysfunction in animal models.
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Product References

Adenosine A2A receptors modify motor function in MPTP-treated common marmosets. - Adenosine A2A receptors modify motor function in MPTP-treated common marmosets.

Kanda T, Tashiro T, Kuwana Y, Jenner P. Neuroreport. 1998 Aug 24;9(12):2857-60.

Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy - Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy

Shiozaki S, Ichikawa S, Nakamura J, Kitamura S, Yamada K, Kuwana Y. Psychopharmacology (Berl). 1999 Nov;147(1):90-5.