ISX 9

• Supplier: Tocris Bioscience
• Catalog: 5147
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Cas Number: 832115-62-5
• Chemical Name: N-Cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide
• Formula: C11H10N2O2S
• Molecular Weight: 234.27
• Purity: >99 %
• Description: Neurogenic agent. Mediates neuroD reporter gene induction via activation of Ca 2+ influx; increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. Induces neuronal differentiation in human cortical neuronal cells (HCN), adult mouse whole brain (MWB) and subventricular zone (SVZ) progenitors. Also shown to induce cardiomyogenic differentiation of Notch-activated epicardium-derived cells in vitro .

Product References

Small-molecule activation of neuronal cell fate. - Small-molecule activation of neuronal cell fate.

Schneider JW, Gao Z, Li S, Farooqi M, Tang TS, Bezprozvanny I, Frantz DE, Hsieh J. Nat Chem Biol. 2008 Jul;4(7):408-10.

A small molecule differentiation inducer increases insulin production by - A small molecule differentiation inducer increases insulin production by

Dioum EM, Osborne JK, Goetsch S, Russell J, Schneider JW, Cobb MH. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20713-8. doi:

Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene - Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene

Zhang L, Li P, Hsu T, Aguilar HR, Frantz DE, Schneider JW, Bachoo RM, Hsieh J. Differentiation. 2011 Apr;81(4):233-42.

Targeting native adult heart progenitors with cardiogenic small molecules. - Targeting native adult heart progenitors with cardiogenic small molecules.

Russell JL, Goetsch SC, Aguilar HR, Frantz DE, Schneider JW. ACS Chem Biol. 2012 Jun 15;7(6):1067-76.