| Name | ITD 1 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4596 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1099644-42-4 |
| Chemical Name | 4-[1,1'-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylicacidethylester |
| Formula | C27H29NO3 |
| Molecular Weight | 415.52 |
| Purity | >98 % |
| Description | Selective inhibitor of TGF- β signaling (IC 50 = 0.85 μ M); displays little or no inhibition of activin, Wnt or BMP signaling pathways. Induces proteasomal degradation of the TGF- β type II receptor. Inhibits TGF- β -induced mesoderm formation from mouse embryonic stem cells (ESCs) during early differentiation; selectively promotes the differentiation of ESCs to cardiomyocytes in vitro between days 3-5. Does not induce differentiation of vascular smooth muscle cells or endothelial cells. |
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Willems E, Cabral-Teixeira J, Schade D, Cai W, Reeves P, Bushway PJ, Lanier M, Walsh C, Kirchhausen T, Izpisua Belmonte JC, Cashman J, Mercola M. Cell Stem Cell. 2012 Aug 3;11(2):242-52.
Kinney MA, McDevitt TC. Trends Biotechnol. 2013 Feb;31(2):78-84.