ITE

• Supplier: Tocris Bioscience
• Catalog: 5068
• Prices: $199.00
• Sizes: 10 mg
• Function Type: Agonist
• Cas Number: 448906-42-1
• Chemical Name: 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylicacidmethylester
• Formula: C14H10N2O3S
• Molecular Weight: 286.3
• Purity: >98 %
• Description: Endogenous aryl hydrocarbon receptor (AhR) agonist (K i = 3 nM). Decreases Oct4 levels in U87 glioblastoma cells. Induces stem-like cancer cell differentiation in U87 tumor spheres and inhibits ovarian cancer cell proliferation in vitro . Suppresses tumor growth in U87 and OVCAR-3 cell xenografts in mice. Also inhibits TGF- β -induced human myofibroblast differentiation.

Product References

A ligand for the aryl hydrocarbon receptor isolated from lung. - A ligand for the aryl hydrocarbon receptor isolated from lung.

Song J, Clagett-Dame M, Peterson RE, Hahn ME, Westler WM, Sicinski RR, DeLuca HF. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14694-9. Epub 2002 Oct 30.

The aryl hydrocarbon receptor ligand ITE inhibits TGFbeta1-induced human - The aryl hydrocarbon receptor ligand ITE inhibits TGFbeta1-induced human

Lehmann GM, Xi X, Kulkarni AA, Olsen KC, Pollock SJ, Baglole CJ, Gupta S, Casey AE, Huxlin KR, Sime PJ, Feldon SE, Phipps RP. Am J Pathol. 2011 Apr;178(4):1556-67.

An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and - An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and

Wang K, Li Y, Jiang YZ, Dai CF, Patankar MS, Song JS, Zheng J. Cancer Lett. 2013 Oct 28;340(1):63-71.

Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer - Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer

Cheng J, Li W, Kang B, Zhou Y, Song J, Dan S, Yang Y, Zhang X, Li J, Yin S, Cao H, Yao H, Zhu C, Yi W, Zhao Q, Xu X, Zheng M, Zheng S, Li L, Shen B, Wang YJ. Nat Commun. 2015 Jun 10;6:7209.