IU1

• Supplier: Tocris Bioscience
• Catalog: 3792
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 314245-33-5
• Chemical Name: 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone
• Formula: C18H21FN2O
• Molecular Weight: 300.37
• Purity: >98 %
• Description: Selective inhibitor of Usp14; inhibits the catalytic activity of proteasome-associated Usp14 in vitro (IC 50 < 4 μ M). Stimulates proteasome activity and substrate degradation.

Product References

Enhancement of proteasome activity by a small-molecule inhibitor of USP14. - Enhancement of proteasome activity by a small-molecule inhibitor of USP14.

Lee BH, Lee MJ, Park S, Oh DC, Elsasser S, Chen PC, Gartner C, Dimova N, Hanna J, Gygi SP, Wilson SM, King RW, Finley D. Nature. 2010 Sep 9;467(7312):179-84.

Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. - Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes.

Lee MJ, Lee BH, Hanna J, King RW, Finley D. Mol Cell Proteomics. 2011 May;10(5):R110.003871.