IWP 2

• Supplier: Tocris Bioscience
• Catalog: 5279
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 686770-61-6
• Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
• Formula: C22H18N4O2S3
• Molecular Weight: 466.6
• Purity: >98 %
• Description: Inhibitor of Wnt processing and secretion. Inactivates PORCN, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. Blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β -catenin accumulation. Suppresses self-renewal in R1 embryonic stem cells.

Product References

Small molecule-mediated disruption of Wnt-dependent signaling in tissue - Small molecule-mediated disruption of Wnt-dependent signaling in tissue

Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, Wei S, Hao W, Kilgore J, Williams NS, Roth MG, Amatruda JF, Chen C, Lum L. Nat Chem Biol. 2009 Feb;5(2):100-7.

Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast - Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast

ten Berge D, Kurek D, Blauwkamp T, Koole W, Maas A, Eroglu E, Siu RK, Nusse R. Nat Cell Biol. 2011 Aug 14;13(9):1070-5.

Robust cardiomyocyte differentiation from human pluripotent stem cells via - Robust cardiomyocyte differentiation from human pluripotent stem cells via

Lian X, Hsiao C, Wilson G, Zhu K, Hazeltine LB, Azarin SM, Raval KK, Zhang J, Kamp TJ, Palecek SP. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):E1848-57. doi: