IWP 4

• Supplier: Tocris Bioscience
• Catalog: 3533
• Prices: $185.00, $755.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 686772-17-8
• Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
• Formula: C23H20N4O3S3
• Molecular Weight: 496.62
• Purity: >98 %
• Description: Potent inhibitor of Wnt/ β -catenin signaling (IC 50 = 25 nM). Has minimal effect on Notch and Hedgehog signaling pathways. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.

Product References

Small molecule-mediated disruption of Wnt-dependent signaling in tissue - Small molecule-mediated disruption of Wnt-dependent signaling in tissue

Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, Wei S, Hao W, Kilgore J, Williams NS, Roth MG, Amatruda JF, Chen C, Lum L. Nat Chem Biol. 2009 Feb;5(2):100-7.

Robust cardiomyocyte differentiation from human pluripotent stem cells via - Robust cardiomyocyte differentiation from human pluripotent stem cells via

Lian X, Hsiao C, Wilson G, Zhu K, Hazeltine LB, Azarin SM, Raval KK, Zhang J, Kamp TJ, Palecek SP. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):E1848-57. doi:

Differentiation of human epidermal neural crest stem cells (hEPI-NCSC) into - Differentiation of human epidermal neural crest stem cells (hEPI-NCSC) into

Narytnyk A, Verdon B, Loughney A, Sweeney M, Clewes O, Taggart MJ, Sieber-Blum M. Stem Cell Rev. 2014 Apr;10(2):316-26.