(±)-J 113397

• Supplier: Tocris Bioscience
• Catalog: 2507
• Prices: $265.00, $1,085.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 217461-40-0
• Chemical Name: (±)-1-[(3R*,4R*)-1-(Cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
• Formula: C24H37N3O2
• Molecular Weight: 399.57
• Purity: >98 %
• Description: Potent and selective NOP receptor antagonist (IC 50 values are 2.3, 1400, 2200 and > 10000 nM for NOP, κ , μ and δ -opioid receptors respectively). Inhibits nociceptin/orphanin FQ-induced hyperalgesia in the mouse tail-flick test.

Product References

Discovery of the first potent and selective small molecule opioid receptor-like - Discovery of the first potent and selective small molecule opioid receptor-like

Kawamoto H, Ozaki S, Itoh Y, Miyaji M, Arai S, Nakashima H, Kato T, Ohta H, Iwasawa Y. J Med Chem. 1999 Dec 16;42(25):5061-3.

In vitro and in vivo pharmacological characterization of J-113397, a potent and - In vitro and in vivo pharmacological characterization of J-113397, a potent and

Ozaki S, Kawamoto H, Itoh Y, Miyaji M, Azuma T, Ichikawa D, Nambu H, Iguchi T, Iwasawa Y, Ohta H. Eur J Pharmacol. 2000 Aug 18;402(1-2):45-53.

The nociceptin/orphanin FQ receptor antagonist J-113397 and L-DOPA additively - The nociceptin/orphanin FQ receptor antagonist J-113397 and L-DOPA additively

Marti M, Trapella C, Viaro R, Morari M. J Neurosci. 2007 Feb 7;27(6):1297-307.