J 113863

• Supplier: Tocris Bioscience
• Catalog: 2598
• Prices: $95.00, $199.00, $825.00
• Sizes: 1 mg, 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 353791-85-2
• Chemical Name: 1,4-cis-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidiniumiodide
• Formula: C30H37Cl2IN2O2
• Molecular Weight: 655.44
• Purity: >98 %
• Description: Potent chemokine receptor 1 (CCR1) antagonist (IC 50 values are 0.9 and 5.8 nM for human and mouse CCR1 receptors respectively). Also displays high selectivity for human but not mouse CCR3 receptors (IC 50 values are 0.58 and 460 nM respectively). Improves paw inflammation, joint damage and dramatically reduces cell infiltration into joints in collagen-induced arthritis in mice. Isomer of UCB 35625 (Cat. No. 2757).

Product References

Design, synthesis, and discovery of a novel CCR1 antagonist. - Design, synthesis, and discovery of a novel CCR1 antagonist.

Naya A, Sagara Y, Ohwaki K, Saeki T, Ichikawa D, Iwasawa Y, Noguchi K, Ohtake N. J Med Chem. 2001 Apr 26;44(9):1429-35.

Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine - Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine

Amat M, Benjamim CF, Williams LM, Prats N, Terricabras E, Beleta J, Kunkel SL, Godessart N. Br J Pharmacol. 2006 Nov;149(6):666-75. Epub 2006 Oct 3.