J 147

• Supplier: Tocris Bioscience
• Catalog: 2595
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Cas Number: 1146963-51-0
• Chemical Name: 2,2,2-Trifluoroaceticacid1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
• Formula: C18H17F3N2O2
• Molecular Weight: 350.33
• Purity: >99 %
• Description: Potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC 50 = 25 - 200 nM). Reduces soluble A β 40 and A β 42 levels and increases BDNF levels in the hippocampus in vivo . Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active.

Product References

A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. - A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease.

Chen Q, Prior M, Dargusch R, Roberts A, Riek R, Eichmann C, Chiruta C, Akaishi T, Abe K, Maher P, Schubert D. PLoS One. 2011;6(12):e27865.

Metabolism of a potent neuroprotective hydrazide. - Metabolism of a potent neuroprotective hydrazide.

Chiruta C, Zhao Y, Tang F, Wang T, Schubert D. Bioorg Med Chem. 2013 May 15;21(10):2733-41.

The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's - The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's

Prior M, Dargusch R, Ehren JL, Chiruta C, Schubert D. Alzheimers Res Ther. 2013 May 14;5(3):25.