Jervine

• Supplier: Tocris Bioscience
• Catalog: 2792
• Prices: $225.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 469-59-0
• Chemical Name: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one
• Formula: C27H39NO3
• Molecular Weight: 425.6
• Purity: >98 %
• Description: Inhibitor of Hedgehog signaling (IC 50 = 500 - 700 nM); binds directly to Smoothened (Smo). Inhibits the response of target tissues to Sonic hedgehog signaling, possibly via the sterol sensing domain of Patched. Teratogenic.

Product References

Teratogen-mediated inhibition of target tissue response to Shh signaling. - Teratogen-mediated inhibition of target tissue response to Shh signaling.

Cooper MK, Porter JA, Young KE, Beachy PA. Science. 1998 Jun 5;280(5369):1603-7.

Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell - Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell

ten Berge D, Brouwer A, Korving J, Reijnen MJ, van Raaij EJ, Verbeek F, Gaffield W, Meijlink F. Development. 2001 Aug;128(15):2929-38.

Identification of a small molecule inhibitor of the hedgehog signaling pathway: - Identification of a small molecule inhibitor of the hedgehog signaling pathway:

Williams JA, Guicherit OM, Zaharian BI, Xu Y, Chai L, Wichterle H, Kon C, Gatchalian C, Porter JA, Rubin LL, Wang FY. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4616-21. Epub 2003 Apr 4.