JHW 007 hydrochloride

Name JHW 007 hydrochloride
Supplier Tocris Bioscience
Catalog 4717
Prices $175.00, $709.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 202645-74-7
Chemical Name (3-endo)-3-[Bis(4-fluorophenyl)methoxy]-8-butyl-8-azabicyclo[3.2.1]octanehydrochloride
Formula C24H29F2NO.HCl
Molecular Weight 421.95
Purity >99 %
Description Dopamine uptake inhibitor; displays high affinity for the dopamine transporter (DAT) (K i = 25 nM compared to 1330 and 1730 for NET and SERT respectively). Suppresses the effects of cocaine administration in a dose-dependent manner and decreases cocaine and methamphetamine self-administration in rats.
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Product References

Dopamine transporter-dependent and -independent striatal binding of the - Dopamine transporter-dependent and -independent striatal binding of the

Kopajtic TA, Liu Y, Surratt CK, Donovan DM, Newman AH, Katz JL. J Pharmacol Exp Ther. 2010 Dec;335(3):703-14.

The high affinity dopamine uptake inhibitor, JHW 007, blocks cocaine-induced - The high affinity dopamine uptake inhibitor, JHW 007, blocks cocaine-induced

Velazquez-Sanchez C, Ferragud A, Murga J, Carda M, Canales JJ. Eur Neuropsychopharmacol. 2010 Jul;20(7):501-8. doi: