JIB 04

• Supplier: Tocris Bioscience
• Catalog: 4351
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 199596-05-9
• Chemical Name: 5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine
• Formula: C17H13ClN4
• Molecular Weight: 308.76
• Purity: >99 %
• Description: Pan Jumonji histone demethylase inhibitor (IC 50 values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). Exhibits negligible activity at PHD2 and TET1. Selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo . Prolongs survival in a mouse model of breast cancer.

Product References

Azinyl and diazinyl hydrazones derived from aryl N-heteroaryl ketones: synthesis - Azinyl and diazinyl hydrazones derived from aryl N-heteroaryl ketones: synthesis

Easmon J, Heinisch G, Purstinger G, Langer T, Osterreicher JK, Grunicke HH, Hofmann J. J Med Chem. 1997 Dec 19;40(26):4420-5.

A small molecule modulates Jumonji histone demethylase activity and selectively - A small molecule modulates Jumonji histone demethylase activity and selectively

Wang L, Chang J, Varghese D, Dellinger M, Kumar S, Best AM, Ruiz J, Bruick R, Pena-Llopis S, Xu J, Babinski DJ, Frantz DE, Brekken RA, Quinn AM, Simeonov A, Easmon J, Martinez ED. Nat Commun. 2013;4:2035.