JJKK 048

• Supplier: Tocris Bioscience
• Catalog: 1565
• Prices: $195.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 1515855-97-6
• Chemical Name: 4-[Bis(1,3-benzodioxol-5-yl)methyl]-1-piperidinyl]-1H-1,2,4-triazol-1-yl-methanone
• Formula: C23H22N4O5
• Molecular Weight: 434.44
• Purity: >98 %
• Description: Potent and selective monoacylglycerol lipase (MAGL) inhibitor (IC 50 = 0.4 nM). Exhibits >13,000 and ~630-fold selectivity for MAGL over FAAH and ABHD6 respectively.

Product References

Piperazine and piperidine triazole ureas as ultrapotent and highly selective - Piperazine and piperidine triazole ureas as ultrapotent and highly selective

Aaltonen N, Savinainen JR, Ribas CR, Ronkko J, Kuusisto A, Korhonen J, Navia-Paldanius D, Hayrinen J, Takabe P, Kasnanen H, Pantsar T, Laitinen T, Lehtonen M, Pasonen-Seppanen S, Poso A, Nevalainen T, Laitinen JT. Chem Biol. 2013 Mar 21;20(3):379-90.

Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis - Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis

Laitinen T, Navia-Paldanius D, Rytilahti R, Marjamaa JJ, Karizkova J, Parkkari T, Pantsar T, Poso A, Laitinen JT, Savinainen JR. Mol Pharmacol. 2014 Mar;85(3):510-9.