JKC 363

Name JKC 363
Supplier Tocris Bioscience
Catalog 3341
Prices $139.00
Sizes 500 µg
Function Type Antagonist
Cas Number 436083-30-6
Formula C69H91N19O16S2
Molecular Weight 1506.72
Description Potent and selective melanocortin MC 4 receptor antagonist (IC 50 values are 0.5 and 44.9 nM at MC 4 and MC 3 respectively) that antagonizes the effects of α -MSH. Suppresses thyrotropin-releasing hormone (TRH) release, attenuates food intake and reduces formalin-induced pain in vivo .
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Product References

Effects of melanocortin receptor ligands on thyrotropin-releasing hormone - Effects of melanocortin receptor ligands on thyrotropin-releasing hormone

Kim MS, Small CJ, Russell SH, Morgan DG, Abbott CR, alAhmed SH, Hay DL, Ghatei MA, Smith DM, Bloom SR. J Neuroendocrinol. 2002 Apr;14(4):276-82.

Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity - Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity

Bellasio S, Nicolussi E, Bertorelli R, Reggiani A. Eur J Pharmacol. 2003 Dec 15;482(1-3):127-32.

Evidence for an interaction between CB1 cannabinoid and melanocortin MCR-4 - Evidence for an interaction between CB1 cannabinoid and melanocortin MCR-4

Verty AN, McFarlane JR, McGregor IS, Mallet PE. Endocrinology. 2004 Jul;145(7):3224-31. Epub 2004 Mar 19.