JLK 6

Name JLK 6
Supplier Tocris Bioscience
Catalog 3426
Prices $149.00, $629.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 62252-26-0
Chemical Name 7-Amino-4-chloro-3-methoxy-1H-2-benzopyran
Formula C10H8ClNO3
Molecular Weight 225.63
Purity >99 %
Description Inhibitor of γ -secretase that selectively inhibits β APP cleavage without affecting other γ -secretase-mediated pathways. Prevents recovery of A β 40 and A β 42 from HEK293 cell overexpressing wild-type or Swedish-mutated β APP (IC 50 ~ 30 μ M) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α -secretase, the proteosome or GSK3 β .
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