JMV 449

Name JMV 449
Supplier Tocris Bioscience
Catalog 2575
Prices $105.00
Sizes 1 mg
Function Type Agonist
Cas Number 139026-66-7
Formula C38H66N8O7
Molecular Weight 746.96
Description Potent, metabolically stable neurotensin receptor agonist peptide (IC 50 = 0.15 nM for inhibition of [ 125 I]-NT binding to neonatal mouse brain; EC 50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo .
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Product References

Reduced peptide bond pseudopeptide analogues of neurotensin: binding and - Reduced peptide bond pseudopeptide analogues of neurotensin: binding and

Lugrin D, Vecchini F, Doulut S, Rodriguez M, Martinez J, Kitabgi P. Eur J Pharmacol. 1991 Nov 26;205(2):191-8.

JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and - JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and

Dubuc I, Costentin J, Doulut S, Rodriguez M, Martinez J, Kitabgi P. Eur J Pharmacol. 1992 Aug 25;219(2):327-9.

Neuroprotective effect of the neurotensin analogue JMV-449 in a mouse model of - Neuroprotective effect of the neurotensin analogue JMV-449 in a mouse model of

Torup L, Borsdal J, Sager T. Neurosci Lett. 2003 Nov 20;351(3):173-6.