JNJ 10181457 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1998
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 544707-20-2
• Chemical Name: 4-[3-[4-[Piperidinyl]but-1-ynyl]benzyl]morpholinedihydrochloride
• Formula: C20H28N2O.2HCl
• Molecular Weight: 385.37
• Purity: >98 %
• Description: Histamine H 3 receptor antagonist (pK i values are 8.15 and 8.93 for rat and human H 3 receptors respectively). Increases extracellular norepinephrine and acetylcholine levels in rat frontal cortex but does not stimulate dopamine release. Brain penetrant.

Product References

Histamine H3 receptor antagonists: from target identification to drug leads. - Histamine H3 receptor antagonists: from target identification to drug leads.

Bonaventure P, Letavic M, Dugovic C, Wilson S, Aluisio L, Pudiak C, Lord B, Mazur C, Kamme F, Nishino S, Carruthers N, Lovenberg T. Biochem Pharmacol. 2007 Apr 15;73(8):1084-96. Epub 2006 Nov 3.

The histamine H3 receptor: an attractive target for the treatment of cognitive - The histamine H3 receptor: an attractive target for the treatment of cognitive

Esbenshade TA, Browman KE, Bitner RS, Strakhova M, Cowart MD, Brioni JD. Br J Pharmacol. 2008 Jul;154(6):1166-81.

JNJ-10181457, a selective non-imidazole histamine H(3) receptor antagonist, - JNJ-10181457, a selective non-imidazole histamine H(3) receptor antagonist,

Galici R, Boggs JD, Aluisio L, Fraser IC, Bonaventure P, Lord B, Lovenberg TW. Neuropharmacology. 2009 Jun;56(8):1131-7.