JNJ 10191584 maleate

• Supplier: Tocris Bioscience
• Catalog: 4019
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 869497-75-6
• Chemical Name: 1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazinemaleate
• Formula: C13H15ClN4O.C4H4O4
• Molecular Weight: 394.81
• Purity: >99 %
• Description: Highly selective histamine H 4 receptor silent antagonist; binds with high affinity to the human H 4 receptor (K i = 26 nM). > 540-fold selective over the H 3 receptor (K i = 14.1 μ M). Inhibits mast cell and eosinophil chemotaxis in vitro with IC 50 values of 138 and 530 nM respectively. Orally active in vivo .

Product References

Synthesis and structure-activity relationships of indole and benzimidazole - Synthesis and structure-activity relationships of indole and benzimidazole

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Inhibitory effects of histamine H4 receptor antagonists on experimental colitis - Inhibitory effects of histamine H4 receptor antagonists on experimental colitis

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Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole - Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole

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