JNJ 10397049

• Supplier: Tocris Bioscience
• Catalog: 2441
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 708275-58-5
• Chemical Name: N-(2,4-Dibromophenyl)-N'-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]-urea
• Formula: C19H20Br2N2O3
• Molecular Weight: 484.18
• Purity: >99 %
• Description: Selective OX 2 receptor antagonist (pIC 50 = 7.4 for chimeric OX 2 receptors; pK B values are 5.9 and 8.5 for OX 1 and OX 2 receptors respectively). Shows no significant activity in a panel of over 50 other neurotransmitters and neuropeptide receptors. Achieves high level of OX 2 receptor occupancy in the rat brain; exhibits sleep-promoting effects in rats.

Product References

Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced - Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced

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Functional magnetic resonance imaging reveals different neural substrates for the - Functional magnetic resonance imaging reveals different neural substrates for the

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Chimeric, mutant orexin receptors show key interactions between orexin receptors, - Chimeric, mutant orexin receptors show key interactions between orexin receptors,

Tran DT, Bonaventure P, Hack M, Mirzadegan T, Dvorak C, Letavic M, Carruthers N, Lovenberg T, Sutton SW. Eur J Pharmacol. 2011 Sep 30;667(1-3):120-8.