JNJ 16259685

• Supplier: Tocris Bioscience
• Catalog: 4317
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 409345-29-5
• Chemical Name: (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
• Formula: C20H23NO3
• Molecular Weight: 325.41
• Purity: >98 %
• Description: Sub-nanomolar potent, non-competitive mGlu 1 antagonist (K i = 0.34 nM). Inhibits glutamate-induced Ca 2+ response at the human mGlu 1 receptor with an IC 50 value of 0.55 nM. Selective over mGlu 5 (> 400-fold) and displays no activity at mGlu 2 , mGlu 3 , mGlu 4 , mGlu 6 , AMPA or NMDA receptors (IC 50 > 10 μ M). Centrally active following systemic administration.

Product References

JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor - JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor

Lavreysen H, Wouters R, Bischoff F, Nobrega Pereira S, Langlois X, Blokland S, Somers M, Dillen L, Lesage AS. Neuropharmacology. 2004 Dec;47(7):961-72.

Synthesis, structure-activity relationship, and receptor pharmacology of a new - Synthesis, structure-activity relationship, and receptor pharmacology of a new

Mabire D, Coupa S, Adelinet C, Poncelet A, Simonnet Y, Venet M, Wouters R, Lesage AS, Van Beijsterveldt L, Bischoff F. J Med Chem. 2005 Mar 24;48(6):2134-53.

Metabotropic glutamate receptor 1 blockade impairs acquisition and retention in a - Metabotropic glutamate receptor 1 blockade impairs acquisition and retention in a

Steckler T, Oliveira AF, Van Dyck C, Van Craenendonck H, Mateus AM, Langlois X, Lesage AS, Prickaerts J. Behav Brain Res. 2005 Oct 14;164(1):52-60.

Effects of mGluR1 antagonism in the dorsal hippocampus on drug context-induced - Effects of mGluR1 antagonism in the dorsal hippocampus on drug context-induced

Xie X, Ramirez DR, Lasseter HC, Fuchs RA. Psychopharmacology (Berl). 2010 Jan;208(1):1-11.