| Name | JNJ 17203212 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3262 |
| Prices | $169.00, $705.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 821768-06-3 |
| Chemical Name | 4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide |
| Formula | C17H15F6N5O |
| Molecular Weight | 419.32 |
| Purity | >99 % |
| Description | Reversible, competitive and potent TRPV1 antagonist (pK i values are 6.5, 7.1 and 7.3 at rat, guinea pig and human TRPV1 respectively). Inhibits capsaicin- and H + -induced channel activation (pIC 50 values are 6.32 and 7.23 respectively) and exhibits antitussive and analgesic activity in vivo . |
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Ghilardi JR, Rohrich H, Lindsay TH, Sevcik MA, Schwei MJ, Kubota K, Halvorson KG, Poblete J, Chaplan SR, Dubin AE, Carruthers NI, Swanson D, Kuskowski M, Flores CM, Julius D, Mantyh PW. J Neurosci. 2005 Mar 23;25(12):3126-31.
Swanson DM, Dubin AE, Shah C, Nasser N, Chang L, Dax SL, Jetter M, Breitenbucher JG, Liu C, Mazur C, Lord B, Gonzales L, Hoey K, Rizzolio M, Bogenstaetter M, Codd EE, Lee DH, Zhang SP, Chaplan SR, Carruthers NI. J Med Chem. 2005 Mar 24;48(6):1857-72.
Bhattacharya A, Scott BP, Nasser N, Ao H, Maher MP, Dubin AE, Swanson DM, Shankley NP, Wickenden AD, Chaplan SR. J Pharmacol Exp Ther. 2007 Nov;323(2):665-74. Epub 2007 Aug 9.