| Name | JNJ 27141491 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3361 |
| Prices | $235.00, $965.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 871313-59-6 |
| Chemical Name | 3-[(1S)-1-(3,4-Difluorophenyl)propyl]-2,3-dihydro-5-(5-isoxazolyl)-2-thioxo-1H-imidazole-4-carboxylicacidmethylester |
| Formula | C17H15F2N3O3S |
| Molecular Weight | 379.38 |
| Purity | >98 % |
| Description | Potent, noncompetitive human CCR2 antagonist; inhibits MCP-1-induced Ca 2+ mobilization in hCCR2-CHO cells (IC 50 = 13 nM). Exhibits selectivity for CCR2 over CCR1, CCR3-8 and CXCR1-3. Delays onset and reduces neurological signs in an experimental autoimmune encephalomyelitis model of multiple sclerosis in hCCR2 knock-in mice. Orally active. |
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