| Name | JNJ 47965567 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3899 |
| Prices | $195.00, $805.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 1428327-31-4 |
| Chemical Name | 2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide |
| Formula | C28H32N4O2S |
| Molecular Weight | 488.64 |
| Purity | >98 % |
| Description | Potent and selective P2X 7 antagonist (pIC 50 values are 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively). Selective over a panel of 50 other receptors, ion channels and transporters. Reduces BzATP -induced IL-1 β release from monocytes in vitro and from rat brain in vivo . Attenuates amphetamine -induced hyperactivity in rats. Brain penetrant. |
| Supplier Page | Shop |
Bhattacharya A, Wang Q, Ao H, Shoblock JR, Lord B, Aluisio L, Fraser I, Nepomuceno D, Neff RA, Welty N, Lovenberg TW, Bonaventure P, Wickenden AD, Letavic MA. Br J Pharmacol. 2013 Oct;170(3):624-40.
Letavic MA, Lord B, Bischoff F, Hawryluk NA, Pieters S, Rech JC, Sales Z, Velter AI, Ao H, Bonaventure P, Contreras V, Jiang X, Morton KL, Scott B, Wang Q, Wickenden AD, Carruthers NI, Bhattacharya A. ACS Med Chem Lett. 2013 Mar 12;4(4):419-22.