JNJ 5207852 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4018
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 398473-34-2
• Chemical Name: 1-[3-[4-(1-Piperidinylmethyl)phenoxy]propyl]piperidinehydrochloride
• Formula: C20H32N2O.2HCl
• Molecular Weight: 389.4
• Purity: >99 %
• Description: High affinity histamine H 3 receptor neutral antagonist (pK i values are 8.9 and 9.2 in rat and human respectively). Brain penetrant and orally active. Has 3- and 100-fold higher affinity than thioperamide (Cat. No. 0644) for rat and human H 3 receptors respectively. Suppresses slow-wave sleep; exhibits wake-promoting effects in rodent arousal models.

Product References

Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 - Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3

Barbier AJ, Berridge C, Dugovic C, Laposky AD, Wilson SJ, Boggs J, Aluisio L, Lord B, Mazur C, Pudiak CM, Langlois X, Xiao W, Apodaca R, Carruthers NI, Lovenberg TW. Br J Pharmacol. 2004 Nov;143(5):649-61. Epub 2004 Oct 4.

Effects of histamine H(3) antagonists and donepezil on learning and mnemonic - Effects of histamine H(3) antagonists and donepezil on learning and mnemonic

Jia F, Kato M, Dai H, Xu A, Okuda T, Sakurai E, Okamura N, Lovenberg TW, Barbier A, Carruthers NI, Iinuma K, Yanai K. Neuropharmacology. 2006 Mar;50(4):404-11. Epub 2005 Nov 28.

Correlation between ex vivo receptor occupancy and wake-promoting activity of - Correlation between ex vivo receptor occupancy and wake-promoting activity of

Le S, Gruner JA, Mathiasen JR, Marino MJ, Schaffhauser H. J Pharmacol Exp Ther. 2008 Jun;325(3):902-9.