JNJ 63533054

• Supplier: Tocris Bioscience
• Catalog: 4020
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 1802326-66-4
• Chemical Name: 3-Chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide
• Formula: C17H17ClN2O2
• Molecular Weight: 316.78
• Purity: >98 %
• Description: Potent and selective GPR139 agonist (EC 50 = 16 nM). Selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142. Brain and cell penetrant. Orally bioavailable.

Product References

The first potent and selective non-imidazole human histamine H4 receptor - The first potent and selective non-imidazole human histamine H4 receptor

Jablonowski JA, Grice CA, Chai W, Dvorak CA, Venable JD, Kwok AK, Ly KS, Wei J, Baker SM, Desai PJ, Jiang W, Wilson SJ, Thurmond RL, Karlsson L, Edwards JP, Lovenberg TW, Carruthers NI. J Med Chem. 2003 Sep 11;46(19):3957-60.

A potent and selective histamine H4 receptor antagonist with anti-inflammatory - A potent and selective histamine H4 receptor antagonist with anti-inflammatory

Thurmond RL, Desai PJ, Dunford PJ, Fung-Leung WP, Hofstra CL, Jiang W, Nguyen S, Riley JP, Sun S, Williams KN, Edwards JP, Karlsson L. J Pharmacol Exp Ther. 2004 Apr;309(1):404-13. Epub 2004 Jan 13.

In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor - In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor

Strakhova MI, Cuff CA, Manelli AM, Carr TL, Witte DG, Baranowski JL, Vortherms TA, Miller TR, Rundell L, McPherson MJ, Adair RM, Brito AA, Bettencourt BM, Yao BB, Wetter JM, Marsh KC, Liu H, Cowart MD, Brioni JD, Esbenshade TA. Br J Pharmacol. 2009 May;157(1):44-54.