| Name | (+)-JQ1 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5603 |
| Prices | $319.00 |
| Sizes | 10 mg |
| Function Type | Inhibitor |
| Cas Number | 1268524-70-4 |
| Chemical Name | (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-aceticacid1,1-dimethylethylester |
| Formula | C23H25ClN4O2S |
| Molecular Weight | 456.99 |
| Purity | >98 % |
| Description | Potent, high affinity, selective BET bromodomain inhibitor (IC 50 values are 17.7, 32.6, 76.9 and 12942 nM for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively; K d values are 49, 59.5, 82, 90.1, 128 and 190 nM for BRD4 (N), BRD3 (N), BRD3 (C), BRD4 (C), BRD2 (N) and BRDT (N) respectively). Induces squamous differentiation in NUT midline carcinoma (NMC) cell lines; inhibits tumor growth in NMC xenograft models in vivo . Exhibits reversible contraceptive effects in germ cells from male mice. Inactive analog (-)-JQ1 available. |
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