JTC 801

• Supplier: Tocris Bioscience
• Catalog: 4499
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 244218-51-7
• Chemical Name: N-(4-Amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]benzamidehydrochloride
• Formula: C26H25N3O2.HCl
• Molecular Weight: 447.96
• Purity: >98 %
• Description: High affinity, selective NOP receptor antagonist (K i = 8.2 nM). Displays approximately 12.5-, 129- and 1055-fold selectivity over human μ -, κ - and δ -opioid receptors respectively. Exhibits anti-nociceptive effects in acute pain models in vivo . Orally active.

Product References

4-Aminoquinolines: novel nociceptin antagonists with analgesic activity. - 4-Aminoquinolines: novel nociceptin antagonists with analgesic activity.

Shinkai H, Ito T, Iida T, Kitao Y, Yamada H, Uchida I. J Med Chem. 2000 Nov 30;43(24):4667-77.

Pharmacological profiles of a novel opioid receptor-like1 (ORL(1)) receptor - Pharmacological profiles of a novel opioid receptor-like1 (ORL(1)) receptor

Yamada H, Nakamoto H, Suzuki Y, Ito T, Aisaka K. Br J Pharmacol. 2002 Jan;135(2):323-32.

Anti-allodynic and anti-hyperalgesic effects of nociceptin receptor antagonist, - Anti-allodynic and anti-hyperalgesic effects of nociceptin receptor antagonist,

Tamai H, Sawamura S, Takeda K, Orii R, Hanaoka K. Eur J Pharmacol. 2005 Mar 14;510(3):223-8.