JTE 013

• Supplier: Tocris Bioscience
• Catalog: 2481
• Prices: $205.00
• Sizes: 10 mg
• Function Type: Antagonist
• Cas Number: 547756-93-4
• Chemical Name: 1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide
• Formula: C17H19N7OCl2
• Molecular Weight: 408.29
• Purity: >98 %
• Description: Sphingosine-1-phosphate (S1P) receptor antagonist, highly selective for S1P 2 (EDG-5). Inhibits S1P binding to human S1P 2 receptors with an IC 50 value of 17.6 nM. At concentrations up to 10 μ M, displays 4.2% inhibition of S1P 3 and does not antagonize S1P 1 . Enhances S1P-induced angiogenesis in vivo .

Product References

Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle - Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle

Ohmori T, Yatomi Y, Osada M, Kazama F, Takafuta T, Ikeda H, Ozaki Y. Cardiovasc Res. 2003 Apr 1;58(1):170-7.

Sphingosine 1-phosphate and lysophosphatidic acid receptors: agonist and - Sphingosine 1-phosphate and lysophosphatidic acid receptors: agonist and

Parrill AL, Sardar VM, Yuan H. Semin Cell Dev Biol. 2004 Oct;15(5):467-76.