JTE 607 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 2392
• Prices: $235.00, $965.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 188791-09-5
• Chemical Name: N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanineethylesterdihydrochloride
• Formula: C25H31Cl2N3O5.2HCl
• Molecular Weight: 597.36
• Purity: >98 %
• Description: Cytokine release inhibitor. Inhibits production of IL-1 β , IL-8, IL-6, IL-10 and TNF α (IC 50 values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs. Reduces proinflammatory cytokine-release and attenuates lung permeability in a rat lung injury model. Induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model.

Product References

JTE-607, a novel inflammatory cytokine synthesis inhibitor without - JTE-607, a novel inflammatory cytokine synthesis inhibitor without

Kakutani M, Takeuchi K, Waga I, Iwamura H, Wakitani K. Inflamm Res. 1999 Aug;48(8):461-8.

JTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung - JTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung

Jian MY, Koizumi T, Tsushima K, Kubo K. Eur J Pharmacol. 2004 Mar 19;488(1-3):231-8.

JTE-607, a multiple cytokine production inhibitor, induces apoptosis accompanied - JTE-607, a multiple cytokine production inhibitor, induces apoptosis accompanied

Tajima N, Fukui K, Uesato N, Maruhashi J, Yoshida T, Watanabe Y, Tojo A. Cancer Sci. 2010 Mar;101(3):774-81.