| Name | JW 67 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4906 |
| Prices | $149.00, $629.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 442644-28-2 |
| Chemical Name | Trispiro[3H-indole-3,2'-[1,3]dioxane-2'',3'''-[3H]indole]-2,2'''(1H,1'''H)-dione |
| Formula | C21H18N2O6 |
| Molecular Weight | 394.38 |
| Purity | >97 % |
| Description | Inhibitor of canonical Wnt pathway signaling (IC 50 = 1.17 μ M); targets the β -catenin destruction complex (GSK-3 β /AXIN/APC) to induce β -catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF- κ B pathways. Blocks G 1 /S cell cycle progression in colorectal cancer (CRC) cell lines (GI 50 = 7.8 μ M). |
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Waaler J, Machon O, von Kries JP, Wilson SR, Lundenes E, Wedlich D, Gradl D, Paulsen JE, Machonova O, Dembinski JL, Dinh H, Krauss S. Cancer Res. 2011 Jan 1;71(1):197-205.
Shultz MD, Kirby CA, Stams T, Chin DN, Blank J, Charlat O, Cheng H, Cheung A, Cong F, Feng Y, Fortin PD, Hood T, Tyagi V, Xu M, Zhang B, Shao W. J Med Chem. 2012 Feb 9;55(3):1127-36.