JW 74

• Supplier: Tocris Bioscience
• Catalog: 4651
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 863405-60-1
• Chemical Name: 4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine
• Formula: C24H20N6O2S
• Molecular Weight: 456.52
• Purity: >99 %
• Description: Inhibitor of canonical Wnt signaling (IC 50 = 790 nM). Targets the β -catenin destruction complex (GSK-3ß/AXIN/APC). Increases AXIN2 and decreases active β -catenin levels in colorectal cancer (CRC) cells. Also arrests cell cycle in G 1 and inhibits proliferation of CRC cells in vitro . Inhibits tumor growth and formation in mouse models.

Product References

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The third transmembrane helix of the cannabinoid receptor plays a role in the - The third transmembrane helix of the cannabinoid receptor plays a role in the

Chin CN, Murphy JW, Huffman JW, Kendall DA. J Pharmacol Exp Ther. 1999 Nov;291(2):837-44.

Pharmacology of cannabinoid receptor ligands. - Pharmacology of cannabinoid receptor ligands.

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