JZL 195

• Supplier: Tocris Bioscience
• Catalog: 3836
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1210004-12-8
• Chemical Name: 4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylicacid4-nitrophenylester
• Formula: C24H23N3O5
• Molecular Weight: 433.46
• Purity: >98 %
• Description: Dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) (IC 50 values are 2 and 4 nM respectively). Elevates anandamide and 2-arachidonoylglycerol levels in vivo . Shown to impair short-term memory in mice.

Product References

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by - Dual blockade of FAAH and MAGL identifies behavioral processes regulated by

Long JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, Jin X, Burston JJ, Sim-Selley LJ, Lichtman AH, Wiley JL, Cravatt BF. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20270-5. doi:

Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces - Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces

Wise LE, Long KA, Abdullah RA, Long JZ, Cravatt BF, Lichtman AH. ACS Chem Neurosci. 2012 May 16;3(5):369-78.

Characterization of the effects of reuptake and hydrolysis inhibition on - Characterization of the effects of reuptake and hydrolysis inhibition on

Wiskerke J, Irimia C, Cravatt BF, De Vries TJ, Schoffelmeer AN, Pattij T, Parsons LH. ACS Chem Neurosci. 2012 May 16;3(5):407-17.