K 41498

Name K 41498
Supplier Tocris Bioscience
Catalog 1683
Prices $395.00
Sizes 1 mg
Function Type Antagonist
Cas Number 434938-41-7
Formula C162H276N48O46
Molecular Weight 3632.26
Description Potent and highly selective CRF 2 receptor antagonist (K i values are 0.66, 0.62 and 425 nM for human CRF 2 α , CRF 2 β and CRF 1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in hCRF 2 α - and hCRF 2 β -expressing cells. In rats in vivo , blocks urocortin-induced hypotension following systemic administration.
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Product References

The highly selective CRF(2) receptor antagonist K41498 binds to presynaptic - The highly selective CRF(2) receptor antagonist K41498 binds to presynaptic

Lawrence AJ, Krstew EV, Dautzenberg FM, Ruhmann A. Br J Pharmacol. 2002 Jul;136(6):896-904.

Design, synthesis and pharmacological characterization of new highly selective - Design, synthesis and pharmacological characterization of new highly selective

Ruhmann A, Chapman J, Higelin J, Butscha B, Dautzenberg FM. Peptides. 2002 Mar;23(3):453-60.