K 579

• Supplier: Tocris Bioscience
• Catalog: 2070
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 440100-64-1
• Chemical Name: (2S)-1-[[[4-Methyl-1-(2-pyrimidinyl)-4-piperidinyl]amino]acetyl]-2-pyrrolidinecarbonitrile
• Formula: C17H24N6O
• Molecular Weight: 328.41
• Purity: >99 %
• Description: Dipeptidyl peptidase IV inhibitor. Inhibits rat, canine, human and monkey enzymes with IC 50 values of 3, 5, 8, and 8 nM respectively. Long-acting hypoglycemic agent; attenuates glucose excursion following glucose loading in Zucker fatty rats.

Product References

K579, a slow-binding inhibitor of dipeptidyl peptidase IV, is a long-acting - K579, a slow-binding inhibitor of dipeptidyl peptidase IV, is a long-acting

Takasaki K, Iwase M, Nakajima T, Ueno K, Nomoto Y, Nakanishi S, Higo K. Eur J Pharmacol. 2004 Feb 23;486(3):335-42.

Effects of combination treatment with dipeptidyl peptidase IV inhibitor and - Effects of combination treatment with dipeptidyl peptidase IV inhibitor and

Takasaki K, Nakajima T, Ueno K, Nomoto Y, Higo K. J Pharmacol Sci. 2004 Jun;95(2):291-3.

Involvement of the active metabolites in the inhibitory activity of K579 on rat - Involvement of the active metabolites in the inhibitory activity of K579 on rat

Takasaki K, Takada H, Nakajima T, Ueno K, Ushiki J, Higo K. Eur J Pharmacol. 2004 Nov 28;505(1-3):237-41.