K 858

• Supplier: Tocris Bioscience
• Catalog: 2790
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 72926-24-0
• Chemical Name: N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
• Formula: C13H15N3O2S
• Molecular Weight: 277.34
• Purity: >99 %
• Description: Selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor (IC 50 = 1.3 μ M). Induces mitotic arrest, caspase-3 activation and cell growth inhibition in HCT116 cells. Displays no effect on microtubule dynamics. Preferentially induces mitotic arrest in cancer cells.

Product References

K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell - K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell

Nakai R, Iida S, Takahashi T, Tsujita T, Okamoto S, Takada C, Akasaka K, Ichikawa S, Ishida H, Kusaka H, Akinaga S, Murakata C, Honda S, Nitta M, Saya H, Yamashita Y. Cancer Res. 2009 May 1;69(9):3901-9.