K-252c

• Supplier: Tocris Bioscience
• Catalog: 3144
• Prices: $165.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 85753-43-1
• Chemical Name: 6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
• Formula: C20H13N3O
• Molecular Weight: 311.34
• Purity: >99 %
• Description: Inhibitor of protein kinase C (IC 50 = 2.45 μ M) that displays ~ 10-fold selectivity over protein kinase A (IC 50 = 25.7 μ M). Also inhibits β -lactamase, malate dehydrogenase and chymotrypsin (IC 50 values are 8, 8 and 10 μ M respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC 50 values range from 0.13 - 0.32 μ M). Shows no activity against herpes simplex virus (HSV).

Product References

Protein kinase C inhibitors; structure-activity relationships in K252c-related - Protein kinase C inhibitors; structure-activity relationships in K252c-related

Fabre S, Prudhomme M, Rapp M. Bioorg Med Chem. 1993 Sep;1(3):193-6.

Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus - Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus

Zimmermann A, Wilts H, Lenhardt M, Hahn M, Mertens T. Antiviral Res. 2000 Oct;48(1):49-60.

Kinase inhibitors: not just for kinases anymore. - Kinase inhibitors: not just for kinases anymore.

McGovern SL, Shoichet BK. J Med Chem. 2003 Apr 10;46(8):1478-83.